国际眼科纵览

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角膜新生血管的治疗进展

张海萍1 迟玮2 华夏1   

  1. 1天津医科大学第二医院眼科, 天津 300070;2 中山大学 中山眼科中心,广州 510060
  • 收稿日期:2019-05-09 出版日期:2019-10-22 发布日期:2019-10-30
  • 通讯作者: 华夏,Email:cathayhuaxia@163.com
  • 基金资助:
    国家自然科学基金(81870638;81670816)

Therapeutic advances of corneal neovascularization

Zhang Haiping1, Chi Wei2, Hua Xia1   

  1. 1 Department of Ophthalmology, Second Hospital, Tianjin Medical University, Tianjin 300070, China;
    2 Zhongshan Ophthalmic Center, Sun Yat\|sen University, Guangzhou 510060, China
  • Received:2019-05-09 Online:2019-10-22 Published:2019-10-30
  • Contact: Hua Xia, Email: cathayhuaxia@163.com
  • Supported by:
    National Natural Science Foundation of China (81870638;81670816)

摘要:

角膜新生血管可导致角膜透明性降低,使视力下降甚至丧失,在各种角膜病变中均可发生。目前已采取大量措施(如应用糖皮质激素、免疫抑制剂、非甾体抗炎药物、抗VEGF药物、酪氨酸激酶抑制剂、某些天然提取物、激光治疗、细针透热治疗、基因治疗、联合治疗等)预防和治疗角膜新生血管,并且取得了不同程度的成功。然而,这些治疗角膜新生血管的方法只是部分有效,并且可能会导致一些副作用。本文旨在对角膜新生血管新的治疗方法加以综述。(国际眼科纵览,2019, 43:332-336)

Abstract:

Corneal neovascularization can lead to corneal hyalinity, visual acuity decline or even loss, which occurs in various corneal diseases. At present, many methods and measures (such as the use of glucocorticoids, immunosuppressive agents, non\|steroidal anti\|inflammatory drugs, anti\|vascular endothelial gowth factor drugs, tyrosine kinase inhibitors, some natural extracts, laser therapy, fine needle diathermy, gene therapy, combination therapy, etc.) have been used to prevent and treat corneal neovascularization, and have achieved varying degrees of success. However, these treatments for corneal neovascularization are only partially effective and may lead to some side effects. This article aims to review the latest treatment of corneal neovascularization.(Int Rev Ophthalmol, 2019, 43:   332\|336)